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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T5178 | AZ876 | Liver X Receptor | |
AZ876 is a potent, highly selective LXR agonist with Ki/EC50 of 7/6 nM and 11/73 nM for hLXRα and hLXRβ respectively. | |||
T1801 | SR9243 | Liver X Receptor | |
SR9243, an LXR inverse agonist, can induce LXR-corepressor interaction; shows anticancer activity and selectively targets the lipogenesis and Warburg effect. | |||
T16930 | SR9238 | Liver X Receptor | |
SR9238 is a synthetic agonist of liver X receptor inverse (IC50s: 214 nM and 43 nM for LXRα and LXRβ, respectively). | |||
T15427 | GSK2033 | Liver X Receptor | |
GSK2033 is an antagonist of LXR (pIC50s: 7 and 7.4 for LXRα or LXRβ, respectively). | |||
T7529 | Yamogenin | Others | |
Yamogenin is a diastereomer of diosgenin, which we have identified as the compound responsible for the anti-hyperlipidemic effect of fenugreek. | |||
T2768 | Saikosaponin A | NF-κB , Antibacterial , Liver X Receptor | |
Saikosaponin A has a variety of pharmacological benefits, including antiepileptic, anti-osteoporosis, antioxidant, anti-in ammatory, immunomodulatory, and anti-bacterial activities. It can effectively attenuate neuropath... | |||
T27478 | GSK3987 | Liver X Receptor | |
GSK3987 is an LXR ligand. GSK3987 recruits the steroid receptor coactivator-1 to human LXRalpha and LXRbeta with EC50s of 40 nM. | |||
T7768 | RGX-104 | RGX-104 free Acid | Liver X Receptor |
RGX-104 (RGX-104 free Acid) free Acid is an agonist of potent liver-X nuclear hormone receptor (LXR) | |||
T1783 | LXR-623 | LXR623,WAY 252623 | Liver X Receptor |
LXR-623 (WAY 252623) is an orally bioavailable and highly specifical synthetic modulator of LXR. | |||
T6310 | GW3965 hydrochloride | GW3965 HCl | Liver X Receptor |
GW3965 hydrochloride (GW3965 HCl) is an effective and specific LXR agonist for hLXRα/β (EC50: 190/30 nM). | |||
T2601 | Vidofludimus | SC12267,4sc-101 | Dehydrogenase , DNA/RNA Synthesis , Interleukin |
Vidofludimus (SC12267) (4SC-101, SC12267) is a novel small molecule inhibitor of dihydroorotate dehydrogenase (DHODH). | |||
T2810 | (20S)-Protopanaxatriol | 20(S)-APPT,g-PPT | Apoptosis , Estrogen Receptor/ERR , Glucocorticoid Receptor , Estrogen/progestogen Receptor , Liver X Receptor |
(20S)-Protopanaxatriol (g-PPT)(g-PPT), a metabolite of ginsenoside, could regulate endothelial cell functions through the estrogen receptor and glucocorticoid receptor. | |||
TQ0274 | 27-Hydroxycholesterol | 25(R)-27-hydroxy Cholesterol | Estrogen/progestogen Receptor , Liver X Receptor |
27-Hydroxycholesterol (25(R)-27-hydroxy Cholesterol) is a selective modulator of estrogen receptor and an agonist of the liver X receptor. | |||
T5128 | RGX-104 hydrochloride | SB742881,RGX-104 HCl | Liver X Receptor |
RGX-104 hydrochloride (SB742881) is a liver X receptor (LXR) agonist with potential immunomodulating and antineoplastic activities. It modulates innate immunity via transcriptional activation of the ApoE gene. | |||
T3970 | BMS-779788 | XL652,EXEL04286652,XL 652,XL-652,BMS-788 | Liver X Receptor |
BMS-779788 (XL-652) is an LXRα/β partial agonist (IC50: 68/14 nM). | |||
T6690 | T0901317 | Apoptosis , FXR , Liver X Receptor , ROR | |
T0901317 is a potent and selective agonist for both LXR and FXR, with EC50 of ~50 nM and 5 μM, respectively; it inhibits nuclear factor/κB (NF/κB). | |||
T16792 | Rovazolac | ALX-101 | Liver X Receptor |
Rovazolac (ALX-101) is a liver x receptor (LXR) modulator used in the study of immune system disorders and atopic dermatitis. | |||
T63896 | BE1218 | Liver X Receptor | |
BE1218 is a liver X receptor (LXR) inverse agonist active on LXRα and LXRβ with an IC50 of 9 nM and 7 nM, respectively. | |||
T27496 | GSK9772 | GSK-9772,GSK 9772 | |
GSK9772 is a transrepression-selective liver X receptor modulators with anti-inflammatory activity. | |||
T71756 | 24(S),25-Epoxycholesterol | ||
24(S),25-Epoxycholesterol is an oxysterol agonist of the liver X receptor. |